Purpose-built Technology Powers the First Integrated Development & Manufacturing Organization (IDMO)
Reagent Vault System (RVS)
Capacity for up to 200 automation-friendly reagent bottles (SLTDs)
SLTDs come in three volumes: 10mL, 50mL, 1000mL
Reagent agnostic (all vendors supported)
Refrigerated at 4°C
Just in time lane for time critical reagent delivery
Integrated software for reagent scheduling, inventory and supply chain management
All SLTDs undergo hydrogen peroxide decontamination cycles
Reagent Vault System (RVS)
Capacity for up to 200 automation-friendly reagent bottles (SLTDs)
SLTDs come in three volumes: 10mL, 50mL, 1000mL
Reagent agnostic (all vendors supported)
Refrigerated at 4°C
Just in time lane for time critical reagent delivery
Integrated software for reagent scheduling, inventory and supply chain management
All SLTDs undergo hydrogen peroxide decontamination cycles
QC - Automated Sampling & Online Analysis
Automated sample collection
Online analysis: integrated cell culture analyzer supports 16 assays including cell count and viability
Offline analysis: sample containers can be collected from the Cell Shuttle
Real-time process monitoring
Auto-generated electronic batch records
QC - Automated Sampling & Online Analysis
Automated sample collection
Online analysis: integrated cell culture analyzer supports 16 assays including cell count and viability
Offline analysis: sample containers can be collected from the Cell Shuttle
Real-time process monitoring
Auto-generated electronic batch records
4x Sterile Liquid Transfer Systems (SLTS)
Facilitates mating of Cellares’ Consumable Cartridge and automation friendly reagent bottles (SLTDs)
Performs all sterile liquid transfer operations including reagent addition and sampling
4x Sterile Liquid Transfer Systems (SLTS)
Facilitates mating of Cellares’ Consumable Cartridge and automation friendly reagent bottles (SLTDs)
Performs all sterile liquid transfer operations including reagent addition and sampling
Material Handling System (MHS)
Automates the transfer of Consumable Cartridges (CC) and automation-friendly reagent bottles (SLTDs)
Transfers occur between feedthroughs, reagent vault system (RVS) and instruments (BPS and SLTS)
Material Handling System (MHS)
Automates the transfer of Consumable Cartridges (CC) and automation-friendly reagent bottles (SLTDs)
Transfers occur between feedthroughs, reagent vault system (RVS) and instruments (BPS and SLTS)
16x Bioprocessing Systems (BPS)
Counterflow Centrifugal Elutriation (CCE)
Magnetic Selection (MS)
Electroporation (EP)
Bioreactor System (BRS)
16x Bioprocessing Systems (BPS)
Counterflow Centrifugal Elutriation (CCE)
Magnetic Selection (MS)
Electroporation (EP)
Bioreactor System (BRS)
Integrated and Flexible Software Suite
Process Design Studio supports 90% of cell therapy modalities (auto & allo) in a single cartridge design
Integrated MES allows for batch scheduling across Cell Shuttle fleet
Real-time process monitoring solution
Auto-generation of electronic batch records
Integrates with 3rd party software systems (ERP, MES, LIMS)
Integrated and Flexible Software Suite
Process Design Studio supports 90% of cell therapy modalities (auto & allo) in a single cartridge design
Integrated MES allows for batch scheduling across Cell Shuttle fleet
Real-time process monitoring solution
Auto-generation of electronic batch records
Integrates with 3rd party software systems (ERP, MES, LIMS)
Cell Shuttle Feedthrough
Up to 16 cartridges can be loaded asynchronously for multi-product, concurrent manufacturing
Each cartridge can run a different cell therapy process as defined in the Process Design Studio
Each cartridge can produce a different batch/product
The feedthrough is the entry and exit point for all Consumable Cartridges
All cartridges undergo hydrogen peroxide decontamination cycles
Cell Shuttle Feedthrough
Up to 16 cartridges can be loaded asynchronously for multi-product, concurrent manufacturing
Each cartridge can run a different cell therapy process as defined in the Process Design Studio
Each cartridge can produce a different batch/product
The feedthrough is the entry and exit point for all Consumable Cartridges
All cartridges undergo hydrogen peroxide decontamination cycles
Cell Shuttle Sterility Paradigm
Each batch/product has a dedicated set of pre-sterilized automation-friendly reagent bottles (SLTDs) and one Consumable Cartridge. Each of these consumable sets constitutes a closed system
The Cell Shuttle maintains an internal ISO8 cleanroom environment
The Cell Shuttle can be deployed in controlled not-classified environments (CNC)
All consumables undergo hydrogen peroxide decontamination cycles as they enter the feedthrough or the reagent vault system (RVS)
Cell Shuttle Sterility Paradigm
Each batch/product has a dedicated set of pre-sterilized automation-friendly reagent bottles (SLTDs) and one Consumable Cartridge. Each of these consumable sets constitutes a closed system
The Cell Shuttle maintains an internal ISO8 cleanroom environment
The Cell Shuttle can be deployed in controlled not-classified environments (CNC)
All consumables undergo hydrogen peroxide decontamination cycles as they enter the feedthrough or the reagent vault system (RVS)
Rapid Access Hatches
Used to add time-sensitive materials such as viral vector
Facilitates retrieval of in-process samples for analysis
Rapid Access Hatches
Used to add time-sensitive materials such as viral vector
Facilitates retrieval of in-process samples for analysis
16 batches processed in parallel
75% fewer process failures
90% less labor required
90% less facility space required
The majority of modalities supported (auto & allo)
“Cellares’ revolutionary technology will be a game changer for the cell therapy industry.“
PROF. CARL JUNE, MD
CAR-T Cell Therapy Pioneer,
Cellares Advisory Board Member
INTEGRATED AUTOMATION
Truly Closed and Automated from End-To-End
Electroporators (EP)
Achieves world-class EP efficiency
All EP parameters are customizable via Process Design Suite which enables EP optimization
Supports all common genetic modification technologies (CRISPR, TALEN, ZFN) and reagents
Ability to electroporate infinite number of cells via automated batch processing
Electroporators (EP)
Achieves world-class EP efficiency
All EP parameters are customizable via Process Design Suite which enables EP optimization
Supports all common genetic modification technologies (CRISPR, TALEN, ZFN) and reagents
Ability to electroporate infinite number of cells via automated batch processing
Supported Unit Operations
TRANSFECTION
Peristaltic Pumps
Multiple peristaltic pumps enable multiple process steps to run in parallel on the same cartridge
Pump interfaces are used to facilitate sterile, metered liquid transfer between internal cartridge modules and automation friendly reagent bottles (SLTDs)
Peristaltic Pumps
Multiple peristaltic pumps enable multiple process steps to run in parallel on the same cartridge
Pump interfaces are used to facilitate sterile, metered liquid transfer between internal cartridge modules and automation friendly reagent bottles (SLTDs)
Supported Unit Operations
ENRICHMENT
BUFFER EXCHANGE
CONCENTRATION
SAMPLING
IN-PROCESS QC
SELECTION
ACTIVATION
TRANSDUCTION
TRANSFECTION
EXPANSION
FORMULATION
Fluidic Bus
Integrated valves, sensors, fluid channels, and pumps automate all internal fluid transfers
The Fluidic Bus enables reagent transfers from any module of the cartridge to any other module
The modularity of the Fluidic Bus enables support for the majority of cell therapy modalities (auto & allo) within the same cartridge design
Fluidic Bus
Integrated valves, sensors, fluid channels, and pumps automate all internal fluid transfers
The Fluidic Bus enables reagent transfers from any module of the cartridge to any other module
The modularity of the Fluidic Bus enables support for the majority of cell therapy modalities (auto & allo) within the same cartridge design
Supported Unit Operations
ENRICHMENT
BUFFER EXCHANGE
CONCENTRATION
SAMPLING
IN-PROCESS QC
SELECTION
ACTIVATION
TRANSDUCTION
TRANSFECTION
EXPANSION
FORMULATION
Reagent & Final Product Containers
Smart containers provide precise, real-time volume tracking
Integrated smart containers for starting material, reagent storage and final product formulation
Reagent & Final Product Containers
Smart containers provide precise, real-time volume tracking
Integrated smart containers for starting material, reagent storage and final product formulation
Supported Unit Operations
ENRICHMENT
BUFFER EXCHANGE
CONCENTRATION
SELECTION
ACTIVATION
TRANSDUCTION
TRANSFECTION
EXPANSION
FORMULATION
Bioreactor System (BRS)
Supports expansion of >20 billion cells
Perfusion-enabled stirred-tank design
Closed loop control and real-time monitoring of temperature (T), dissolved oxygen, (DO) and acidity (pH)
Bioreactor System (BRS)
Supports expansion of >20 billion cells
Perfusion-enabled stirred-tank design
Closed loop control and real-time monitoring of temperature (T), dissolved oxygen, (DO) and acidity (pH)
Supported Unit Operations
ACTIVATION
TRANSDUCTION
EXPANSION
Sterile Liquid Transfer Ports (SLTP)
Supports reagent additions, waste removal and automated sampling
SLTPs on the Consumable Cartridge (CC) interface with the SLTPs on the automation-friendly reagent bottles (SLTDs)
The Sterile Liquid Transfer System (SLTS) facilitates metered, automated, sterile liquid transfer into and out of the Consumable Cartridge
Sterile Liquid Transfer Ports (SLTP)
Supports reagent additions, waste removal and automated sampling
SLTPs on the Consumable Cartridge (CC) interface with the SLTPs on the automation-friendly reagent bottles (SLTDs)
The Sterile Liquid Transfer System (SLTS) facilitates metered, automated, sterile liquid transfer into and out of the Consumable Cartridge
Supported Unit Operations
ENRICHMENT
BUFFER EXCHANGE
CONCENTRATION
SAMPLING
IN-PROCESS QC
SELECTION
ACTIVATION
TRANSDUCTION
TRANSFECTION
EXPANSION
FORMULATION
Magnetic Cell Sorter (MS)
Supports magnetic selection with both microbeads and nanobeads (reagent agnostic)
Supports both positive and negative selection
Column-free design operates in batch mode to process any volume of cells
Magnetic Cell Sorter (MS)
Supports magnetic selection with both microbeads and nanobeads (reagent agnostic)
Supports both positive and negative selection
Column-free design operates in batch mode to process any volume of cells
Supported Unit Operations
SELECTION
Counterflow Centrifugal Elutriator (CCE)
Operates in batch mode to process any volume of cells
Can be used at arbitrary times in the workflow as defined in the Process Design Studio
Counterflow Centrifugal Elutriator (CCE)
Operates in batch mode to process any volume of cells
Can be used at arbitrary times in the workflow as defined in the Process Design Studio
Supported Unit Operations
ENRICHMENT
BUFFER EXCHANGE
CONCENTRATION
FORMULATION
The integrated Consumable Cartridge reduces process failure rates by 75%
Automation eliminates opportunities for operator error
Closing the process eliminates opportunities for contamination
ENRICHMENT
BUFFER EXCHANGE
CONCENTRATION
SAMPLING
IN-PROCESS QC
SELECTION
ACTIVATION
TRANSDUCTION
TRANSFECTION
EXPANSION
FORMULATION
“The Cell Shuttle is a quantum leap forward as there is nothing similar in the cell therapy industry. The Cell Shuttle is the first real end-to-end, high-throughput manufacturing solution. It’s not truly end-to-end unless it’s integrated like the Cell Shuttle."
TIMOTHY MOORE
CTO, Allogene Therapeutics,
Cellares Advisory Board Member
SCALABILITY
Enabling Commercial Scale Manufacturing of Cell Therapies
Integrated Automation
All unit operations in one Consumable Cartridge
High Throughput
Up to 16 cartridges for multi-product, concurrent manufacturing