
Fully Integrated, Scalable, Cell Therapy Manufacturing Platform
HIGH THROUGHPUT
Purpose-built Technology Powers the First Integrated Development & Manufacturing Organization (IDMO)

Reagent Vault System (RVS)
- Capacity for up to 200 automation-friendly reagent bottles (SLTDs)
- SLTDs come in three volumes: 10mL, 50mL, 1000mL
- Reagent agnostic (all vendors supported)
- Refrigerated at 4°C
- Just in time lane for time critical reagent delivery
- Integrated software for reagent scheduling, inventory and supply chain management
- All SLTDs undergo ionized hydrogen peroxide decontamination cycles
Reagent Vault System (RVS)
- Capacity for up to 200 automation-friendly reagent bottles (SLTDs)
- SLTDs come in three volumes: 10mL, 50mL, 1000mL
- Reagent agnostic (all vendors supported)
- Refrigerated at 4°C
- Just in time lane for time critical reagent delivery
- Integrated software for reagent scheduling, inventory and supply chain management
- All SLTDs undergo ionized hydrogen peroxide decontamination cycles
QC - Automated Sampling & Online Analysis
- Automated sample collection
- Online analysis: integrated cell culture analyzer supports 16 assays including cell count and viability
- Offline analysis: sample containers can be collected from the Cell Shuttle
- Real-time process monitoring
- Auto-generated electronic batch records
QC - Automated Sampling & Online Analysis
- Automated sample collection
- Online analysis: integrated cell culture analyzer supports 16 assays including cell count and viability
- Offline analysis: sample containers can be collected from the Cell Shuttle
- Real-time process monitoring
- Auto-generated electronic batch records
4x Sterile Liquid Transfer Systems (SLTS)
- Facilitates mating of Cellares’ Consumable Cartridge and automation friendly reagent bottles (SLTDs)
- Performs all sterile liquid transfer operations including reagent addition and sampling
4x Sterile Liquid Transfer Systems (SLTS)
- Facilitates mating of Cellares’ Consumable Cartridge and automation friendly reagent bottles (SLTDs)
- Performs all sterile liquid transfer operations including reagent addition and sampling
Material Handling System (MHS)
- Automates the transfer of Consumable Cartridges (CC) and automation-friendly reagent bottles (SLTDs)
- Transfers occur between feedthroughs, reagent vault system (RVS) and instruments (BPS and SLTS)
Material Handling System (MHS)
- Automates the transfer of Consumable Cartridges (CC) and automation-friendly reagent bottles (SLTDs)
- Transfers occur between feedthroughs, reagent vault system (RVS) and instruments (BPS and SLTS)
16x Bioprocessing Systems (BPS)
- Counterflow Centrifugal Elutriation (CCE)
- Magnetic Selection (MS)
- Electroporation (EP)
- Bioreactor System (BRS)
16x Bioprocessing Systems (BPS)
- Counterflow Centrifugal Elutriation (CCE)
- Magnetic Selection (MS)
- Electroporation (EP)
- Bioreactor System (BRS)
Integrated and Flexible Software Suite
- Process Design Studio supports 90% of cell therapy modalities (auto & allo) in a single cartridge design
- Integrated MES allows for batch scheduling across Cell Shuttle fleet
- Real-time process monitoring solution
- Auto-generation of electronic batch records
- Integrates with 3rd party software systems (ERP, MES, LIMS)
Integrated and Flexible Software Suite
- Process Design Studio supports 90% of cell therapy modalities (auto & allo) in a single cartridge design
- Integrated MES allows for batch scheduling across Cell Shuttle fleet
- Real-time process monitoring solution
- Auto-generation of electronic batch records
- Integrates with 3rd party software systems (ERP, MES, LIMS)
Cell Shuttle Feedthrough
- Up to 16 cartridges can be loaded asynchronously for multi-product, concurrent manufacturing
- Each cartridge can run a different cell therapy process as defined in the Process Design Studio
- Each cartridge can produce a different batch/product
- The feedthrough is the entry and exit point for all Consumable Cartridges
- All cartridges undergo ionized hydrogen peroxide decontamination cycles
Cell Shuttle Feedthrough
- Up to 16 cartridges can be loaded asynchronously for multi-product, concurrent manufacturing
- Each cartridge can run a different cell therapy process as defined in the Process Design Studio
- Each cartridge can produce a different batch/product
- The feedthrough is the entry and exit point for all Consumable Cartridges
- All cartridges undergo ionized hydrogen peroxide decontamination cycles
Cell Shuttle Sterility Paradigm
- Each batch/product has a dedicated set of pre-sterilized automation-friendly reagent bottles (SLTDs) and one Consumable Cartridge. Each set which constitutes a closed system
- The Cell Shuttle maintains an internal ISO8 cleanroom environment
- The Cell Shuttle can be deployed in controlled not-classified environments (CNC)
- All consumables undergo ionized hydrogen peroxide decontamination cycles as they enter the feedthrough or the reagent vault system (RVS)
Cell Shuttle Sterility Paradigm
- Each batch/product has a dedicated set of pre-sterilized automation-friendly reagent bottles (SLTDs) and one Consumable Cartridge. Each set which constitutes a closed system
- The Cell Shuttle maintains an internal ISO8 cleanroom environment
- The Cell Shuttle can be deployed in controlled not-classified environments (CNC)
- All consumables undergo ionized hydrogen peroxide decontamination cycles as they enter the feedthrough or the reagent vault system (RVS)
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16 batches processed in parallel
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75% fewer process failures
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90% less labor required
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90% less facility space required
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90% of modalities supported (auto & allo)

“Cellares’ revolutionary technology will be a game changer for the cell therapy industry.“
INTEGRATED AUTOMATION
Truly Closed and Automated from End-To-End

Electroporators (EP)
- Achieves world-class EP efficiency
- All EP parameters are exposed and customizable via Process Design Suite (no black box) which enables EP optimization
- Supports all common genetic modification technologies (CRISPR, TALEN, ZFN) and reagents
- Ability to electroporate infinite number of cells via automated batch processing
Electroporators (EP)
- Achieves world-class EP efficiency
- All EP parameters are exposed and customizable via Process Design Suite (no black box) which enables EP optimization
- Supports all common genetic modification technologies (CRISPR, TALEN, ZFN) and reagents
- Ability to electroporate infinite number of cells via automated batch processing
Peristaltic Pumps
- Multiple peristaltic pumps enable multiple process steps to run in parallel on the same cartridge
- Pump interfaces are used to facilitate sterile, metered liquid transfer between internal cartridge modules and automation friendly reagent bottles (SLTDs)
Peristaltic Pumps
- Multiple peristaltic pumps enable multiple process steps to run in parallel on the same cartridge
- Pump interfaces are used to facilitate sterile, metered liquid transfer between internal cartridge modules and automation friendly reagent bottles (SLTDs)
Fluidic Bus
- Integrated valves, sensors, fluid channels, and pumps automate all internal fluid transfers
- The Fluidic Bus enables reagent transfers from any module of the cartridge to any other module
- The modularity of the Fluidic Bus enables support for 90% of cell therapy modalities (auto & allo) within the same cartridge design
Fluidic Bus
- Integrated valves, sensors, fluid channels, and pumps automate all internal fluid transfers
- The Fluidic Bus enables reagent transfers from any module of the cartridge to any other module
- The modularity of the Fluidic Bus enables support for 90% of cell therapy modalities (auto & allo) within the same cartridge design
Reagent & Final Product Containers
- Smart containers provide precise, real-time volume tracking
- Integrated smart containers for starting material, reagent storage and final product formulation
Reagent & Final Product Containers
- Smart containers provide precise, real-time volume tracking
- Integrated smart containers for starting material, reagent storage and final product formulation
Bioreactor System (BRS)
- Supports expansion of >20 billion cells
- Perfusion-enabled stirred-tank design
- Closed loop control and real-time monitoring of temperature (T), dissolved oxygen, (DO) and acidity (pH)
Bioreactor System (BRS)
- Supports expansion of >20 billion cells
- Perfusion-enabled stirred-tank design
- Closed loop control and real-time monitoring of temperature (T), dissolved oxygen, (DO) and acidity (pH)
Sterile Liquid Transfer Ports (SLTP)
- Supports reagent additions, waste removal and automated sampling
- SLTPs on the Consumable Cartridge (CC) interface with the SLTPs on the automation-friendly reagent bottles (SLTDs)
- The Sterile Liquid Transfer System (SLTS) facilitates metered, automated, sterile liquid transfer into and out of the Consumable Cartridge
Sterile Liquid Transfer Ports (SLTP)
- Supports reagent additions, waste removal and automated sampling
- SLTPs on the Consumable Cartridge (CC) interface with the SLTPs on the automation-friendly reagent bottles (SLTDs)
- The Sterile Liquid Transfer System (SLTS) facilitates metered, automated, sterile liquid transfer into and out of the Consumable Cartridge
Magnetic Cell Sorter (MS)
- Supports magnetic selection with both microbeads and nanobeads (reagent agnostic)
- Supports both positive and negative selection
- Column-free design operates in batch mode to process any volume of cells
Magnetic Cell Sorter (MS)
- Supports magnetic selection with both microbeads and nanobeads (reagent agnostic)
- Supports both positive and negative selection
- Column-free design operates in batch mode to process any volume of cells
Counterflow Centrifugal Elutriator (CCE)
- Operates in batch mode to process any volume of cells
- Can be used at arbitrary times in the workflow as defined in the Process Design Studio
Counterflow Centrifugal Elutriator (CCE)
- Operates in batch mode to process any volume of cells
- Can be used at arbitrary times in the workflow as defined in the Process Design Studio
The integrated Consumable Cartridge reduces process failure rates by 75%
- Automation eliminates opportunities for operator error
- Closing the process eliminates opportunities for contamination
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ENRICHMENT
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BUFFER EXCHANGE
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CONCENTRATION
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SAMPLING
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IN-PROCESS QC
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SELECTION
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ACTIVATION
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TRANSDUCTION
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TRANSFECTION
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EXPANSION
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FORMULATION


“The Cell Shuttle is a quantum leap forward as there is nothing similar in the cell therapy industry. The Cell Shuttle is the first real end-to-end, high-throughput manufacturing solution. It’s not truly end-to-end unless it’s integrated like the Cell Shuttle."
SCALABILITY
Enabling Commercial Scale Manufacturing of Cell Therapies
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Integrated Automation
All unit operations in one Consumable Cartridge
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High Throughput
Up to 16 cartridges for multi-product, concurrent manufacturing
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Scalability
Up to 2,800 batches per Cell Shuttle per year
FLEXIBLE SOFTWARE
Integrated Software Suite Supports 90% of Cell Therapy Modalities
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SUPPORTED APPLICATIONS
- Autologous & Allogeneic
- CAR-T, TCR, HSC, NK, TIL, Treg, γδ T cells
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FLEXIBLE SOFTWARE
- Process customization via Process Design Studio
- Enables digital process development and DOE
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INTEGRATED HARDWARE
- Every process uses the same modular Consumable Cartridge
- No hardware customization required, which accelerates technology adoption